Overview & Reviews

The base E320 is replaced with the E350 for 2006. The new model name indicates a new engine -- a 3.5-liter V6 with 268 hp, a 20-percent increase from the previous E320.

• Sleek and dignified design inside and out, pleasing blend of ride and handling, sophisticated safety features, all-wheel drive available on both sedan and wagon models.

• More expensive than competitors, confusing control layout, electronically controlled brakes lack progressive feel.

User Reviews:

Showing 1 through 10 of 167.00

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  Mercedes E 350 - 2006 Mercedes-Benz E-Class
  By Jim Ford - December 21 - 9:23 am

  The car is a joy to drive with great performance but has proven to be a little touchy with some smaller issues. We have had problems with seat belt sensors going off even when the belt is fastened. The check oil level light comes on (twice in spite of service) when the oil is fine. The air conditioning is very noisy and the dealer says that is the way it is. Engine performance and fuel economy is terrrific. At times the transmission does not shift smoothly.

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  Wish I agreed - 2006 Mercedes-Benz E-Class
  By John Pflugh - October 8 - 6:40 pm

  Sorry to say I cant agree with most of the E350-4M reviews. It has been back to the dealer 10 times mostly for electrical problems (oil level message, ESP/cruise failure but also incl 2 recalls). Nice ride, good fuel mi (27 hwy) and good performance but the reliability has been a nightmare. This was always my "one day Ill have a MB" - didnt do my normal comparison testing and am paying for it. If you want further quantification just check out the resale - dropped from $57k new to $37k in 14 mos!!

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  Love my Mercedes - 2006 Mercedes-Benz E-Class
  By Mercedes E350 4matic - September 19 - 10:46 pm

  This is the second Mercedes I have owned over the past 5 years. I switched to Acura for a while. The new E350 class is spectacular with the higher horse power (268) over the old 320. I had a S class and was disappointed that they hadnt changed in the last 5 years and went for the new E this time. It is loaded with lots of toys and i highly recommend the integrated SIRIUS satellite radio. Perhaps the best features of this car have to do with how others look at you while you are driving it. I got a special paint, Bordeux Red and it is very sharp and an eye turner. Overall I am very happy with the car and enjoy driving it alot.

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  Great car but behind the times - 2006 Mercedes-Benz E-Class
  By E350Sport - April 6 - 4:00 pm

  I love my new E350 with the sport package. Although the exterior is great, MB falls short in the interior amenities. Horrendous Nav, No bluetooth/ipod. My Lexus blows away the Benz in the interior styling

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  Great Package - 2006 Mercedes-Benz E-Class
  By Nathan - November 11 - 5:40 pm

  This new engine combined with the new 7- speed auto tranny provides brisk performance at any speed. The new tranny seem to be in the right gear at all times and pulls away without hesitation. Roomy and comfortable for long drives too. The layout of the speedo, tach and clock is a bit strange since you find yourself looking at the clock when you want the tach. There is also too much information in the middle part of the speedometer without any logical corollation. The NAV system is vastly improved and highly useful. This is our 7th Mercedes-Benz and so far so good.

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  First Mercedes after a BMW 3-series - 2006 Mercedes-Benz E-Class
  By stormybmw - October 14 - 9:26 pm

  The Mercedes E350 wasnt my first choice for a midsize car. After driving a BMW 3-series for 6 yrs, my obvious choice was a 5-series. The 5-series design is ugly and I-drive is terrible, car was more nimble and fun to drive than an E350. Definitely a beautiful car that turns peoples heads.

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  Nav system is an antique - 2006 Mercedes-Benz E-Class
  By Bill - August 17 - 2:06 pm

  The E320 CDI is very fuel efficient and fun to drive, but the transmission has occassional problems. Slipping during takeoff which my dealer says is normal. Styling is rather bland. Seats could stand to be a little more comfortable. The lumbar support should be power and easier to reach. My biggest complaint is the antique nav system. Somebody must have bought these on a $59 closeout. Charging $2900 for this system should be a felony. Its an unbelievably antiquated system with few features, no touch screen, and no voice command. Also theres no bluetooth unless you buy their phone. I own a 2007 Toyota Camry that blows this car away with superior luxury features. Sorry MB, you need to catch up

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  Nice, but not a Lexus - 2006 Mercedes-Benz E-Class
  By Fast55 - November 11 - 3:50 am

  Ive way more issues with the 06 than my old E55 (2002 W210 E55) although, yes, the 2006 is a rocketship in comparison. MB has lost the "tank like" build quality of the older cars, and doesnt seem to care what the buyer endures as far as problems, but the car is scary fast, and is still the best 4 door hot rod money can buy. Get the build quality up to Lexus standards, and there will be no room for BMW in this market.

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  Mercedes Refinement and American Muscle - 2006 Mercedes-Benz E-Class
  By Teflonman - September 23 - 6:13 pm

  There is not much I can say that has not been already said about this car. Recap: Blistering acceleration (stock 12.5 quarter mile), Long distance highway comfort, and good looks for a sedan. The main draw for alot of people about this car is the ability to modify it north of 550 HP. Its easily done with a few add ons and a tune. It truly exemplifies class with muscle. I had mine at the quarter mile track and people were checking it out hard in disbelief that a sedan could haul like that. With the massive depreciation that Mercedes experience, you cant go wrong getting a used one and purchase an extended warranty. Its just the cost of doing business. ENJOY!

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  Luxurious yes, but its no BMW - 2006 Mercedes-Benz E-Class
  By DonnyMac - June 20 - 10:16 am

  We decided we needed seating for 6-7, but didnt want an SUV. That left the E series and the Volvo V70. The E350 is beautiful, well-appointed and comfortable/luxurious. The suspension and steering, however, are softer than they should be, especially if you are used to driving a BMW with sports suspension (or even an Audi). The Volvo V70 R was sportier in power and handling, and had WAY better front seats (the most comfortable seats I have ever sat in, in fact), but was too stark/dark in the cockpit. Probably, upgrading to the E55 Wagon solves the problem, but for $35k more, thats insane. Come on Mercedes, make it handle more like a German driving machine!